• Aller, S.G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R., Harrell, P.M., Trinh, Y.T., Zhang, Q., Urbatsch, I.L., et al. (2009). Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding. Science 323, 1718–1722.
  • Ambudkar, S.V., Dey, S., Hrycyna, C.A., Ramachandra, M., Pastan, I., and Gottesman, M.M. (1999). Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39, 361–398.
  • Ambudkar, S.V., Kimchi-Sarfaty, C., Sauna, Z.E., and Gottesman, M.M. (2003). P-glycoprotein: from genomics to mechanism. Oncogene 22, 7468–7485.
  • Ford, J.M., and Hait, W.N. (1990). Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 42, 155–199.
  • Fung, K.L., and Gottesman, M.M. (2009). A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function. Biochim Biophys Acta 1794, 860–871.
  • Hrycyna, C.A., Ramachandra, M., Germann, U.A., Cheng, P.W., Pastan, I., and Gottesman, M.M. (1999). Both ATP sites of human P-glycoprotein are essential but not symmetric. Biochemistry 38, 13887–13899.
  • Lam, F.C., Liu, R., Lu, P., Shapiro, A.B., Renoir, J.-M., Sharom, F.J., and Reiner, P.B. (2001). β-Amyloid efflux mediated by p-glycoprotein: β-Amyloid efflux mediated by an ABC transporter. Journal of Neurochemistry 76, 1121–1128.
  • M M Cornwell, D.E.S. (1993). SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. The Journal of Biological Chemistry 268, 19505–19511.
  • Moitra, K., and Dean, M. (2011). Evolution of ABC transporters by gene duplication and their role in human disease. Biol. Chem. 392, 29–37.
  • Padowski, J.M., and Pollack, G.M. (2010). Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation. Methods Mol. Biol. 596, 359–384.
  • Scotto, K.W., and Egan, D.A. (1998). Transcriptional regulation of MDR genes. Cytotechnology 27, 257–269.

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