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Biosynthesis of P-GlycoproteinEdit

P-glycoprotein is commonly been shown to be a constitutively active gene. However, upregulation of the gene can occur through a complex array of environmental signals and stresses. Most regulation that occurs on the P-gp gene has been shown to be mostly positive, as the gene lacks a specific repressor.[1]

The transcription of P-gp is enhanced by an upstream sp1 binding site. Sp1 is present near many genes in which the promoter lacks a TATA box. Deletions of the sp1 binding region have shown a 6 fold decrease in transcription.[2]

Cancer has also been shown to upregulate P-gp, causing cells to efflux at a much higher rate than normal.

Synthesis in HumansEdit

The specific gene sequence of P-Glycoprotein in humans can be found HERE

P-gp is synthesized in most Human cells, however there tends to be a higher accumulation in epithelial cells of the small and large intestines, brain, kidneys and liver. It is predicted that these occur due to the stress of these systems.

More InformationEdit

  1. Yuzo: P-Glycoprotein: Introduction
  2. Yuzo: P-Glycoprotein: Biological function
  3. Yuzo: P-Glycoprotein: Biosynthesis
  4. Yuzo: P-Glycoprotein: Gene sequence
  5. Yuzo: P-Glycoprotein: Amino acid sequence and composition
  6. Yuzo: P-Glycoprotein: Domains and structural motifs
  7. Yuzo: P-Glycoprotein: Interactions with macromolecules and small molecules
  8. Yuzo: P-Glycoprotein: Molecular biodiversity and evolution
  9. Yuzo: P-Glycoprotein: Literature overview
  10. Yuzo: P-Glycoprotein: Online resources

ReferencesEdit

  1. Scotto, K.W., and Egan, D.A. (1998). Transcriptional regulation of MDR genes. Cytotechnology 27, 257–269.
  2. M M Cornwell, D.E.S. (1993). SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. The Journal of Biological Chemistry 268, 19505–19511.

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