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P-Glycoprotein as a TransporterEdit

In the most general scope, P-Glycoprotein is an integral membrane transporter. Specifically it is a part of the ATP Binding Cassette (ABC) family of proteins. It is important to clarify that P-Glycoprotein is an efflux pump, meaning it only moves molecules out of the cell. P-glyoprotein is also known in the ABC family as ATP-binding cassette sub-family B member 1 (ABCB1)

Multi Drug ResistanceEdit

Unlike other transport proteins P-Gp primarily functions in removing xenobiotics from the cell. This is an important defense mechanism for cells, allowing for the efflux of foreign and harmful molecules. It is also plays a
F4.medium

A more accurate representation of P-gp's ability to efflux.

large role in cancer survival as many drugs may become rendered ineffective due to the inability to reach key sections within the cell. Although P-glycoprotein helps export harmful molecules, it is not the sole defense mechanism of the cell, many enzymes and barriers work in conjunction with this protein.







More InformationEdit

  1. Yuzo: P-Glycoprotein: Introduction
  2. Yuzo: P-Glycoprotein: Biological function
  3. Yuzo: P-Glycoprotein: Biosynthesis
  4. Yuzo: P-Glycoprotein: Gene sequence
  5. Yuzo: P-Glycoprotein: Amino acid sequence and composition
  6. Yuzo: P-Glycoprotein: Domains and structural motifs
  7. Yuzo: P-Glycoprotein: Interactions with macromolecules and small molecules
  8. Yuzo: P-Glycoprotein: Molecular biodiversity and evolution
  9. Yuzo: P-Glycoprotein: Literature overview
  10. Yuzo: P-Glycoprotein: Online resources

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