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The images were created using MacPyMol. The particular PBD files of interested used are coded 1TD6 (for the homolog structue) and 1W0E   (cytochrome 3A4 protein).

Overall Structure Cytochrome P450Edit

Sylvie figure 3

The overall structure of CYP3A4 displayed as a ribbon diagram. The diagram is colored according to secondary structure elements (beta strands in yellow, hellces in red, and loops in green).The diagram also features the signature heme pocket in blue. This heme pocket in universal among almost all CYP proteins.


Overall Structure With A Surface RepresentationEdit

Figure 2 sylvie

The CYP protein with a surface representation overlaid on top of a ribbon diagram. The ribbon diagram features the alpha helices in blue, beta sheets in hot pink, and loops in light pink. This image also features the heme pocket in yellow.


Electrostatic Map of CYP3A4Edit

Figure1pymolsylvie

Electrostatic map of CYP protein that highlights the heme binding region that is positively charged. Positively charged regions are shown in blue, negatively charged residues in red. The heme is highlighted in yellow.


Superposition of CYP3A4 and the homologus CYP proteinEdit

Last image

Enlarged image showing two CYP proteins aligned. The protein used in all of the other images, 1W0E, is featured in pink, and its heme pocket in featured in hot pink. The homolog is featured in light purple and its heme pocket is featured in dark purple. The RMS for the two proteins was 2.246 Angstroms, however the RMS for the proteins heme pockets was found to be 0.120 Angstroms.

PagesEdit

  1. Alessandra: Cytochrome p450: Introduction
  2. Alessandra: Cytochrome p450: Biological function
  3. Alessandra: Cytochrome p450: Biosynthesis
  4. Alessandra: Cytochrome p450: Gene sequence
  5. Alessandra: Cytochrome p450: Amino acid sequence and composition
  6. Alessandra: Cytochrome p450: Secondary and tertiary structure
  7. Alessandra: Cytochrome p450: Domains and structural motifs
  8. Alessandra: Cytochrome p450: Interactions with macromolecules and small molecules
  9. Alessandra: Cytochrome p450: Molecular biodiversity and evolution
  10. Alessandra: Cytochrome p450: Literature overview
  11. Alessandra: Cytochrome p450: Useful online resources
  12. Alessandra: Cytochrome p450: Pymol Images

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