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The p53 protein regulates many genes involved in cell cycle regulation and apoptosis, and therefore plays a critical role in maintaining genome stability. p53 accomplishes regulation of target genes by acting as a transcription factor. It binds to specific response elements in p53-regulated genes, controlling expression by either inducing or inhibiting transcription.
p53 is activated when the cell emits stress signals as a result of damage such as double-strand DNA breaks, protein unfolding, or oncogene activation. The severity of the damage as well as the point in the cell cycle at which p53 is activated will determine if the cell undergoes arrest and repair or apoptosis. The ability of p53 to induce apoptosis is critical to its function as a tumor suppressor. Inhibiting this process can lead to proliferation of damaged or toxic cells.
- EBI multiple-database search results for "p53"
- NCBI GQuery multiple-database search results for "p53 tumor suppressor protein"
- PDB Molecule of the month article on p53 tumor suppressor
- PDB search results for p53
- Pfam family P53 (PF00870), P53 DNA-binding domain
- Reference amino acid sequence for p53
- Reference nucleotide sequence of p53 coding sequence
- The p53 website
- Wikipedia article on p53
- Keri: p53: Introduction
- Keri: p53: Biological function
- Keri: p53: Biosynthesis
- Keri: p53: Gene sequence
- Keri: p53: Amino acid sequence and composition
- Keri: p53: Secondary and tertiary structure
- Keri: p53: Domains and structural motifs
- Keri: p53: Interactions with macromolecules and small molecules
- Keri: p53: Molecular biodiversity and evolution
- Keri: p53: Literature overview
- Keri: p53: Useful online resources