p53 regulates several genes involved in a wide variety of cell processes, including cell-cycle arrest, repair, and apoptosis (Riley et al. 2008). It can halt cell growth by stopping the cell cycle when DNA damage is detected. If the damage is repairable, it will activate proteins involved in DNA repair. If the damage is found to be irreparable, p53 will then initiate apoptosis to terminate the cell.
- Rachel Beckermen and Carol Prives. (2010). Transcriptional Regulation by p53 . Cold Spring Harbor Perspectives in Biology, 2(8): a000935.
- Alberto Inga, Francesca Storici, Thomas A Darden, and Michael A Resnick. (2002). Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. Molecular and Cellular Biology, 22(24): 8612–8625.
- Todd Riley, Eduardo Sontag, Patricia Chen, and Arnold Levine. (2008). Transcriptional control of p53-regulated genes . Nature Reviews Molecular Cell Biology, 9(5): 402–412.
- Keri: p53: Introduction
- Keri: p53: Biological function
- Keri: p53: Biosynthesis
- Keri: p53: Gene sequence
- Keri: p53: Amino acid sequence and composition
- Keri: p53: Secondary and tertiary structure
- Keri: p53: Domains and structural motifs
- Keri: p53: Interactions with macromolecules and small molecules
- Keri: p53: Molecular biodiversity and evolution
- Keri: p53: Literature overview
- Keri: p53: Useful online resources