p53 is composed of 393 amino acids and has a molecular weight of 47 kDa.
The NCBI reference sequence for this protein is BAC16799
Amino acid sequence
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Amino acid sequence of p53 reference sequence (FASTA format)
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>gi|23491729|dbj|BAC16799.1| P53 [Homo sapiens] MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAA PRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKT CPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRN TFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVHVCACPGR DRRTEEENLRKKGEPHHELPPGSTKRALSNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALEL KDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Amino acid composition
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Ala (A) 24 6.1% Arg (R) 26 6.6% Asn (N) 14 3.6% Asp (D) 20 5.1% Cys (C) 10 2.5% Gln (Q) 15 3.8% Glu (E) 30 7.6% Gly (G) 23 5.9% His (H) 13 3.3% Ile (I) 8 2.0% Leu (L) 32 8.1% Lys (K) 20 5.1% Met (M) 12 3.1% Phe (F) 11 2.8% Pro (P) 43 10.9% Ser (S) 39 9.9% Thr (T) 22 5.6% Trp (W) 4 1.0% Tyr (Y) 9 2.3% Val (V) 18 4.6%
p53 is highly composed of proline, serine, and leucine, and has smaller quantities of tryptophan, isoleucine, and tyrosine.
Pages
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- Keri: p53: Introduction
- Keri: p53: Biological function
- Keri: p53: Biosynthesis
- Keri: p53: Gene sequence
- Keri: p53: Amino acid sequence and composition
- Keri: p53: Secondary and tertiary structure
- Keri: p53: Domains and structural motifs
- Keri: p53: Interactions with macromolecules and small molecules
- Keri: p53: Molecular biodiversity and evolution
- Keri: p53: Literature overview
- Keri: p53: Useful online resources