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p53 is composed of 393 amino acids and has a molecular weight of 47 kDa. 

The NCBI reference sequence for this protein is BAC16799

Amino acid sequenceEdit

Amino acid sequence of p53 reference sequence (FASTA format)Edit

>gi|23491729|dbj|BAC16799.1| P53 [Homo sapiens]
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAA
PRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKT
CPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRN
TFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVHVCACPGR
DRRTEEENLRKKGEPHHELPPGSTKRALSNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALEL
KDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Amino acid compositionEdit

Ala (A)   24     6.1%
Arg (R)   26     6.6%
Asn (N)   14     3.6%
Asp (D)   20     5.1%
Cys (C)   10     2.5%
Gln (Q)   15     3.8%
Glu (E)   30     7.6%
Gly (G)   23     5.9%
His (H)   13     3.3%
Ile (I)   8      2.0%
Leu (L)   32     8.1%
Lys (K)   20     5.1%
Met (M)   12     3.1%
Phe (F)   11     2.8%
Pro (P)   43    10.9%
Ser (S)   39     9.9%
Thr (T)   22     5.6%
Trp (W)   4      1.0%
Tyr (Y)   9      2.3%
Val (V)   18     4.6%

p53 is highly composed of proline, serine, and leucine, and has smaller quantities of tryptophan, isoleucine, and tyrosine.

PagesEdit

  1. Keri: p53: Introduction
  2. Keri: p53: Biological function
  3. Keri: p53: Biosynthesis
  4. Keri: p53: Gene sequence
  5. Keri: p53: Amino acid sequence and composition
  6. Keri: p53: Secondary and tertiary structure
  7. Keri: p53: Domains and structural motifs
  8. Keri: p53: Interactions with macromolecules and small molecules
  9. Keri: p53: Molecular biodiversity and evolution
  10. Keri: p53: Literature overview
  11. Keri: p53: Useful online resources

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