== Interesting Images from Pymol==
The full structure of MDR1. It is made up of 12 transmembrane helixes and 2 ATP binding subunits.
A surface map of MDR1 in Pymol.
A depiction of the flexible linker region of MDR1. The linker region is missing in the structure but is present between the blue and red colored amino acids.
Homologous Proteins[]
Human MDR 1 compared to Macaca mulatta MDR
multidrug resistance protein [Macaca mulatta] Sequence ID: gb|AAS91648.1|Length: 1283Number of Matches: 1Related Information[PUID&RID=PMSF47G301R&log$=genealign&blast_rank=17 Gene]-associated gene detailsRange 1: 1 to 1283GenPept[46394984&tracks=[key:sequence_track,name:Sequence,display_name:Sequence,id:STD1,category:Sequence,annots:Sequence,ShowLabel:true][key:gene_model_track,CDSProductFeats:false][key:alignment_track,name:other%20alignments,annots:NG%20Alignments%7CRefseq%20Alignments%7CGnomon%20Alignments%7CUnnamed,shown:false]&v=0:1347&appname=ncbiblast&link_loc=fromHSP Graphics] Next Match Previous Match
| Score | Expect | Method | Identities | Positives | Gaps |
|---|---|---|---|---|---|
| 2526 bits(6547) | 0.0 | Compositional matrix adjust. | 1232/1283(96%) | 1254/1283(97%) | 3/1283(0%) |
Query 1 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII 60
MDLEGDRNGGA+KKNFFKLNNKS+KDKKE+KPTVSVFSMFRYSNWLDKLYMVVGTLAAII
Sbjct 1 MDLEGDRNGGAEKKNFFKLNNKSKKDKKERKPTVSVFSMFRYSNWLDKLYMVVGTLAAII 60
Query 61 HGAGLPLMMLVFGEMTDIFANAGNLEDL---MSNITNRSDINDTGFFMNLEEDMTRYAYY 117
HGAGLPLMMLVFG+MTD FANAGNL DL + N TN S+I DT MNLEEDMTRYAYY
Sbjct 61 HGAGLPLMMLVFGDMTDTFANAGNLGDLGALLFNNTNSSNITDTVPVMNLEEDMTRYAYY 120
Query 118 YSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD 177
YSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD
Sbjct 121 YSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD 180
Query 178 DVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILS 237
+VSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISP+LGLSAA WAKILS
Sbjct 181 EVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPILGLSAAAWAKILS 240
Query 238 SFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANI 297
SFTDKELLAYAKAG VAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANI
Sbjct 241 SFTDKELLAYAKAGVVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANI 300
Query 298 SIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFAN 357
SIGAAFLLIYASYALAFWYGTTLVLS EYSIGQVLTVFFSVLIGAFSVGQASPSIEAFAN
Sbjct 301 SIGAAFLLIYASYALAFWYGTTLVLSKEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFAN 360
Query 358 ARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKV 417
ARGAA+EIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKV
Sbjct 361 ARGAAFEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKV 420
Query 418 QSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEP 477
QSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEP
Sbjct 421 QSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEP 480
Query 478 VLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQ 537
VLFATTIAENIRYGRE+VTMDEIEKAVKEANAYDFIMKLP KFDTLVGERGAQLSGGQKQ
Sbjct 481 VLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGERGAQLSGGQKQ 540
Query 538 RIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADV 597
RIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADV
Sbjct 541 RIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADV 600
Query 598 IAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSND 657
IAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNE+ELENAADESKSEID LEMSS+D
Sbjct 601 IAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEIELENAADESKSEIDTLEMSSHD 660
Query 658 SRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFC 717
S SSLIRKRSTRRSVRGSQ QDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFC
Sbjct 661 SGSSLIRKRSTRRSVRGSQGQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFC 720
Query 718 AIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTF 777
AIINGGLQPAFA+IFSKIIG+FTR DD ETK+QNSNLFSLLFL LGI+SFITFFLQGFTF
Sbjct 721 AIINGGLQPAFAVIFSKIIGIFTRNDDAETKQQNSNLFSLLFLVLGIVSFITFFLQGFTF 780
Query 778 GKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVIT 837
GKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLA+IT
Sbjct 781 GKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAIIT 840
Query 838 QNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA 897
QNIANLGTGIIIS IYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEG+GKIA
Sbjct 841 QNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGAGKIA 900
Query 898 TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCF 957
TEAIENFRTVVSLTQEQKFEHMY QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCF
Sbjct 901 TEAIENFRTVVSLTQEQKFEHMYDQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCF 960
Query 958 RFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPL 1017
RFGAYLVAH LMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAK+SAAHIIMIIEKTPL
Sbjct 961 RFGAYLVAHSLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKVSAAHIIMIIEKTPL 1020
Query 1018 IDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
IDSYSTEGL PNTLEGNVTF EVVFNYPTR DIPVLQGLSLEVKKGQTLALVGSSGCGKS
Sbjct 1021 IDSYSTEGLKPNTLEGNVTFNEVVFNYPTRLDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1080
Query 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
TVVQLLERFYDPLAGKVLLDGKEIK+LNVQWLRAHLGIVSQEPILFDCSI+ENIAYGDNS
Sbjct 1081 TVVQLLERFYDPLAGKVLLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSISENIAYGDNS 1140
Query 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
RVVSQEEIVRAAKEANIHAFIESLPNKYST+VGDKGTQLSGGQKQRIAIARALVRQPHIL
Sbjct 1141 RVVSQEEIVRAAKEANIHAFIESLPNKYSTRVGDKGTQLSGGQKQRIAIARALVRQPHIL 1200
Query 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH
Sbjct 1201 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1260
Query 1258 QQLLAQKGIYFSMVSVQAGTKRQ 1280
QQLLAQKGIYFSMVSVQAG KRQ
Sbjct 1261 QQLLAQKGIYFSMVSVQAGAKRQ 1283