Scholarly ArticlesEdit

1. Bailey, David G., et al. "Grapefruit–medication Interactions: Forbidden Fruit or Avoidable Consequences? " CMAJ 185.4 (2013): 309-16. NCBI. Web. 3 Mar. 2014.

2. Baylon, Javier J., Ivan L. Lenov, Stephen G. Silgar, and Emad Tajkhorshid. "Characterizing the Membrane-Bound State of Cytochrome P450 3A4: Structure, Depth of Insertion, and Orientation. " Journal of the American Chemical Society 135.23 (2013): 8542-551. NCBI. Web. 18 Feb. 2014.

3. Hasemann, Charles A., Ravi G. Kurumbali, Sekhar S. Boddupalli, Julian A. Peterson, and Johann Deisenhofer. "Structure and Function of Cytochromes P450: A Comparative Analysis of Three Crystal Structures ." Structure 3.1 (1995): 41-62.Science Direct. Web. 3 Mar. 2014.

4. Lowen, K. S, et al. "Grapefruit Juice Increases Felodipine Oral Availability in Humans by Decreasing Intestinal CYP3A Protein Expression. " Journal of Clinical Investigation 99.10 (1995): 2545-553. NCBI. Web. 3 Mar. 2014.

5. Lynch, Tom, Amy Price. "The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects" Eastern Virginia Medical School, Norfolk, Virginia Am Fam Physician. 2007 Aug 1;76(3):391-396.

6. Nebert, Daniel W., and David W. Russell. “Clinical Importance of Cytochromes P450.The Lancet 360 (2002):1155-162.Http:// Web. 12 Feb. 2014.

7. Ogu, Chris C., and Jan L. Maxa. “Drug Interactions Due to Cytochrome P450.Baylor University Medical Center Proceedings 13.4 (2000): 421-23. NCBI. Web. 15 Feb. 2014.

8. Otey, Christopher R., Marco Landwehr, Jeffrey B. Endelman, Kaori Hiraga, Jesse D. Bloom, and Frances H. Arnold. “Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450.National Center for Biotechnology Information. U.S. National Library of Medicine, 11 Apr. 2006. Web. 12 Feb. 2014.

9. Williams, Pamela A., Jose Cosme, Dijana M. Vinković, Allison Ward, Hayley C. Angrove, Phillip J. Day, Clemens Vonrhein, Ian J. Tickle, and Harren Jhoti. "Crystal Structures of Human Cytochrome P450 3A4 Bound to Metyrapone and Progesterone ." Science 305.5684 (2004): 683-86. Science. Web. 4 Mar. 2014.

10. Woods, Caleb M., Christina Fernandez, Kent L. Kunze, and William M. Atkins. “Allosteric Activation of Cytochrome P450 3A4 by α- Naphthoflavone: Branch Point Regulation Revealed by Isotope Dilution Analysis.Biochemistry 50.46 (2011): 41-51. NCBI. Web. 18 Feb. 2014.

11. Yano, Jason K., Michael R. Wester, Guillaume A. Schoch, Keith J. Griffin, C. David Stout, and Eric F. Johnson. "The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution. " The Journal of Biological Chemistry 279 (2004): 91-94. Web. 10 Mar. 2014.


  1. Alessandra: Cytochrome p450: Introduction
  2. Alessandra: Cytochrome p450: Biological function
  3. Alessandra: Cytochrome p450: Biosynthesis
  4. Alessandra: Cytochrome p450: Gene sequence
  5. Alessandra: Cytochrome p450: Amino acid sequence and composition
  6. Alessandra: Cytochrome p450: Secondary and tertiary structure
  7. Alessandra: Cytochrome p450: Domains and structural motifs
  8. Alessandra: Cytochrome p450: Interactions with macromolecules and small molecules
  9. Alessandra: Cytochrome p450: Molecular biodiversity and evolution
  10. Alessandra: Cytochrome p450: Literature overview
  11. Alessandra: Cytochrome p450: Useful online resources

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